The nuclear receptor Hr46/Hr3 is required in the blood brain barrier of mature males for courtship
Abstract The blood brain barrier (BBB) forms a stringent barrier that protects the brain from components in the circulation that…
Evaluation of deep convolutional neural networks for in situ hybridization gene expression image representation
Abstract High resolution in situ hybridization (ISH) images of the brain capture spatial gene expression at cellular resolution. These spatial…
Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation
Citation: Elorbany R, Popp JM, Rhodes K, Strober BJ, Barr K, Qi G, et al. (2022) Single-cell sequencing reveals lineage-specific…
Isonitrogenous low-carbohydrate diet elicits specific changes in metabolic gene expression in the skeletal muscle of exercise-trained mice
Abstract With the renewed interest in low-carbohydrate diets (LCDs) in the sports field, a few animal studies have investigated their…
Identification of hub genes associated with COVID-19 and idiopathic pulmonary fibrosis by integrated bioinformatics analysis
Abstract Introduction The coronavirus disease 2019 (COVID-19), emerged in late 2019, was caused by severe acute respiratory syndrome coronavirus 2…
Assessing the quality of RNA isolated from human breast tissue after ambient room temperature exposure
Abstract High quality human tissue is essential for molecular research, but pre-analytical conditions encountered during tissue collection could degrade tissue…
Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve
Citation: Chignon A, Argaud D, Boulanger M-C, Mkannez G, Bon-Baret V, Li Z, et al. (2022) Genome-wide chromatin contacts of…
Regulation of gliotoxin biosynthesis and protection in Aspergillus species
Abstract Aspergillus fumigatus causes a range of human and animal diseases collectively known as aspergillosis. A. fumigatus possesses and expresses…
DNA methylation and single-nucleotide polymorphisms in DDX58 are associated with hand, foot and mouth disease caused by enterovirus 71
Abstract Background This research aimed to explore the association between the RIG-I-like receptor (RIG-I and MDA5 encoded by DDX58 and…
Functional analysis of ADARs in planarians supports a bilaterian ancestral role in suppressing double-stranded RNA-response
Abstract ADARs (adenosine deaminases acting on RNA) are known for their adenosine-to-inosine RNA editing activity, and most recently, for their…