Abstract Both the composition of cell types and their spatial distribution in a tissue play a critical role in cellular function, organ development, and disease progression. For example, intratumor heterogeneity…
Citation: Yang Y, Shi L, Fu X, Ma G, Yang Z, Li Y, et al. (2022) Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in…
Abstract A common strategy for the functional interpretation of genome-wide association study (GWAS) findings has been the integrative analysis of GWAS and expression data. Using this strategy, many association methods…
Abstract Chronic inflammation is considered a major driving force for clonal expansion and evolution in the Philadelphia-negative myeloproliferative neoplasms, which include essential thrombocythemia, polycythemia vera and primary myelofibrosis (MPNs). One…
Citation: Lakey BD, Myers KS, Alberge F, Mettert EL, Kiley PJ, Noguera DR, et al. (2022) The essential Rhodobacter sphaeroides CenKR two-component system regulates cell division and envelope biosynthesis. PLoS…
Abstract Background Triatoma infestans is the main vector of Chagas disease in the Southern Cone. The resistance to pyrethroid insecticides developed by populations of this species impairs the effectiveness of…
Abstract Tombusviruses, similar to other (+)RNA viruses, exploit the host cells by co-opting numerous host components and rewiring cellular pathways to build extensive virus-induced replication organelles (VROs) in the cytosol…
Abstract Thymidine kinase 2 (TK2) deficiency in humans leads to a myopathic form of mitochondrial DNA (mtDNA) deficiency. Here we present a skeletal and cardiac muscle specific TK2 knockout mouse…
Abstract Covid-19 progression shows sex-dependent features. It is hypothesized that a better Covid-19 survival rate in females can be attributed to the presence of higher 17β-estradiol (E2) levels in women…
Citation: Martínez VS, Saa PA, Jooste J, Tiwari K, Quek L-E, Nielsen LK (2022) The topology of genome-scale metabolic reconstructions unravels independent modules and high network flexibility. PLoS Comput Biol…
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